Association Between VDR and CYP24A1 Polymorphisms, Atopic Dermatitis, and Biochemical Lipid and Vitamin D Profiles in Spanish Population: Case-Control Study

Background Atopic dermatitis (AD) is the most prevalent inflammatory skin disorder, characterized by impaired epidermal barrier function and an altered immune response, both of which are influenced vitamin D deficiency. Single-nucleotide polymorphisms (SNPs) in VDR CYP24A1 have been previously associated with AD. Objective We sought to characterize associations between lipid biochemical profile children diagnosed Methods A total 246 participants (143 patients AD 103 healthy controls) were enrolled this study. Genotyping for (rs2239185, rs1544410, rs7975232, rs2238136, rs3782905, rs2239179, rs1540339, rs2107301, rs2239182, rs731236) (rs2248359 rs2296241) was performed allele-specific polymerase chain reaction using integrated fluidic circuit technology. Serum levels calcium, phosphorus, measured, determined. Results Among SNPs, rs2239182 exerted a protective effect against development AD, whereas rs2238136 identified as risk factor The GCC haplotype (rs2239185-G, rs1540339-C, rs2238136-C) appeared protect rs2239182-CC higher 25(OH)D concentrations, rs2238136-TT, rs2239185-GA, rs2248359-TT present large proportion serum rs2239185-AA, rs2239182-CC, rs1540339-CC cholesterol; rs2239182-TT lower low-density lipoprotein rs2239182-TC high-density cholesterol. Both SNPs (rs2296241-AA rs2248359-TT) cholesterol levels. Conclusions SNP other CYP24A1, may lead alterations parameters that influence Our findings highlight complex genetic basis indicate interrelationships different factors can metabolism or profiles, turn